Of the following medications, which ones are considered first-line in treatment of an acute manic episode of bipolar disorder (assuming monotherapy)?

Of the following medications, which ones are considered first-line in treatment of an

acute manic episode of bipolar disorder (assuming monotherapy)?

i. Lithium

ii. Fluoxetine

iii. Aripiprazole

iv. Risperidone

v. Ziprasidone

vi. Venlafaxine

vii. Quetiapine

viii. Valproate